News Contact Location Quality Technology Custom Manufacturing Products

VERY WELL POSITIONED FOR THE FUTURE

Arevipharma offers three state-of-the-art, multi-purpose plants with a total reactor volume capacity of 150 m3, whichcomply with the cGMP standard and meet almost all customer requirements.

Pilot Plant for Manufacturing of Active Pharmaceutical Ingredients

The pilot plant is optimally suited to the efficient process development and production of small batch sizes up to 50 kgs. A flexible infrastructure enables us to perform highly complex syntheses even at this scale.

Capacities

  • Reactor volume: 3.3 m³
  • 7 reactors of 250 l and 630 l (glass-lined, stainless steel)
  • Temperature range: -60 °C to +200 °C
  • Pressure: 1 mbar to 25 bar
  • Further processing:
    • Centrifuge and several filters
    • Dryer
    • Sieve
    • Mill
    • Packaging

Multi-Purpose Plant

Capacities

  • Total reactor volumne: 140 m³
  • 37 reactors of 1.6 – 6.3 m³ , glass-lined and stainless steel
  • Temperatue range -10 °C to +160 °C
  • Presssure: 1 mbar to 15 bar
  • Further processing:
    • 12 centrifuges (stainless-steel, hastelloy)
    • 2 filter dryers, 7 vacuum dryers
    • Short way destillation
    • Finishing area with sieves, mills, and mixer
    • Packaging
    • Tank farm: 1200 m³ for 20 solvents

Multi-Purpose Plant for highly active compounds

Capacities

  • Reactor volume: 7.5 m³
  • Reactors with 2.5 m³ of volume, glass-lined
  • Temperature range: -10 °C to +160 °C
  • Temperature-controlled centrifuge with on-site purification
  • Vacuum dryer and hermetic filling
  • isolator box
  • Separate IPC and QC laboratory
  • Lab capacities for process development and scale-up

Our Technologies

Our facilities and our special, longstanding expertise in the synthesis of complex organic compounds allow us to offer to our customers a broad range of synthetic processes and technologies applicable in almost all scales.
  • Acylation
  • Aldol condensation
  • Alkylation
  • Amidation / Amination
  • Cyanation
  • Diels-Alder reactions
  • Epoxidation
  • Friedel-Crafts reaction
  • Grignard reactions
  • Halogenation
  • Hydrogenations
    • catalytically: H2 with Pd/C, RA-nickel or Pt
    • Metal hydrides: NaBH4, LiAlH4
  • Condensation
  • Mannich reactions
  • Organo metallic chemistry with HexLi
  • Oxidation (e.g. Oppenauer)
  • Strecker reaction
  • Racemat separation
  • Reduction
  • Reaction with gases
  • Ritter reactions
  • Rearrangement
  • Esterification
  • Saponification
  • Suzuki coupling
  • Von Braun reaction

  • Handling of corrosive and toxic compounds, e.g. POCl3, SOCl2, NaCN, Br2, HBr, BrCN, methylvinylketone, ethylchloroformiate, epichlorohydrine, N-LOST derivatives
  • Handling of controlled substances and highly potent compounds
  • Milling, micronising, sieving 

GMP kilo lab and second piloting plant

In the year 2017 we will build up a GMP kilo lab and a second piloting plant, where highly potent drugs up to an occupational exposure level (OEL) of less than 1 µg/m³ will be handled safely.

Arevipharma GmbH
Meißner Straße 35
D-01445 Radebeul 		Web: www.arevipharma.com
Telefon: +49 (0)351 8314-0
Telefax: +49 (0)351 8314-2100
 Geschäftsführung
Herr Daniel Hoffmann
Herr Dr. Dirk Jung
 Handelsregister:
Amtsgericht Dresden, HRB 23835
USt-IdNr.: DE 240935001
Contact
Imprint
AGB
Privacy Statement
Copyright © 2019 • Arevipharma GmbH Generiert: 5 ms